Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | C1S | P09871 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28012854 | 0.82 | P2RX7 (0.44) | P2RX7CYP1A2KMT2ACES1NAPRT | |
| Benzene SCHEMBL3466087 | 0.82 | GOT1 (0.46) | P2RX7CYP1A2CES1NAPRTGOT1 | |
| SCHEMBL30068488 | 0.79 | — | — | |
| SCHEMBL26878 | 0.79 | — | — | |
| Maleic Acid SCHEMBL28002349 | 0.79 | P2RX7 (0.42) | P2RX7CYP1A2KMT2ACES1NAPRT | |
| Maleic Acid SCHEMBL28002347 | 0.79 | P2RX7 (0.42) | P2RX7CYP1A2KMT2ACES1NAPRT | |
| Trifluoroacetic Acid SCHEMBL25283802 | 0.79 | P2RX7 (0.50) | P2RX7CYP1A2DPP4DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL28322762 | 0.78 | CXCR4 (0.35) | DPP4DPP8DPP9CDK5CDK5R1 | |
| Trifluoroacetic Acid SCHEMBL30489000 | 0.78 | P2RX7 (0.49) | P2RX7CYP1A2DPP4DPP8DPP9 | |
| Cadaverine Tartrate SCHEMBL27776744 | 0.78 | CYP1A2 (0.47) | P2RX7CYP1A2L3MBTL1KMT2ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702063-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| CN-101600718-B | Imidazo [1,2-B ] pyridazine and pyrazolo [1,5-A ] pyrimidine derivatives and their use as protein kinase inhibitors | SUPERGEN INC | 2013-07-03 | — | — | CN | disclosed |
| WO-2012148775-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-11-01 | — | — | WO | disclosed |
| CN-101654452-A | Heterocyclic compounds and methods of use. | TARGEGEN INC US | 2010-02-24 | — | — | CN | disclosed |
| CN-101600718-A | Imidazo [1, 2-B ] pyridazine and pyrazolo [1, 5-A ] pyrimidine derivatives and their use as protein kinase inhibitors | SUPERGEN INC (US) | 2009-12-09 | — | — | CN | disclosed |