Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738449 | 0.94 | TP53 (0.43) | RECQLMAPTLMNATP53KMT2A | |
| SCHEMBL13736647 | 0.85 | RECQL (0.51) | RECQLMAPTLMNAKMT2AMEN1 | |
| SCHEMBL13738541 | 0.84 | TDP1 (0.51) | RECQLMAPTLMNAKMT2AMEN1 | |
| SCHEMBL16200236 | 0.84 | LMNA (0.44) | MAPTLMNATP53NPC1RAB9A | |
| SCHEMBL23400259 | 0.81 | KMT2A (0.42) | RECQLMAPTTP53KMT2AMEN1 | |
| SCHEMBL13737492 | 0.80 | MAPT (0.57) | MAPTLMNAHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13736773 | 0.77 | RECQL (0.39) | RECQLMAPTKMT2AMEN1MAPK1 | |
| SCHEMBL13826497 | 0.76 | PIK3CD (0.43) | RECQLMAPTLMNAKMT2AMEN1 | |
| SCHEMBL13826210 | 0.76 | PIK3CD (0.43) | RECQLMAPTLMNAKMT2AMEN1 | |
| SCHEMBL16200060 | 0.76 | THRB (0.52) | RECQLMAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2701510-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | Usher III Initiative (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012148994-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE (US) | 2012-11-01 | — | — | WO | disclosed |