Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16556797 | 0.83 | NOTUM (0.53) | RXRAGRIN1GRIN2BPDK2NOTUM | |
| SCHEMBL28071287 | 0.81 | RXRA (0.49) | RXRAGRIN1GRIN2BNOTUMLMNA | |
| SCHEMBL29471936 | 0.79 | NOTUM (0.65) | PDE10ARXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL28266369 | 0.79 | NOTUM (0.65) | PDE10ARXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL5934873 | 0.78 | NOTUM (0.57) | PDK2NOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL254803 | 0.78 | NOTUM (0.63) | DYRK1ANOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL29635591 | 0.78 | NOTUM (0.63) | DYRK1ANOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL27785304 | 0.77 | LMNA (0.45) | PDK2NOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL837064 | 0.77 | NOTUM (0.44) | PDK2NOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL30402678 | 0.77 | NOTUM (0.64) | KCNH2PDK2NOTUMLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |