Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13737313 | 0.81 | PDE10A (0.50) | RXRAGRIN1GRIN2BLMNANOTUM | |
| SCHEMBL25753338 | 0.80 | KAT6A (0.41) | RXRAGRIN1GRIN2BNOTUMKAT6A | |
| SCHEMBL5934873 | 0.78 | NOTUM (0.57) | LMNANOTUMERCC1ERCC4KAT6A | |
| SCHEMBL29635591 | 0.78 | NOTUM (0.63) | LMNANOTUMKAT6AKDM4EALDH1A1 | |
| SCHEMBL254803 | 0.78 | NOTUM (0.63) | LMNANOTUMKAT6AKDM4EALDH1A1 | |
| SCHEMBL27769009 | 0.77 | CRHR1 (0.40) | LMNAKAT6AKDM4EALDH1A1MAPK1 | |
| SCHEMBL837064 | 0.77 | NOTUM (0.44) | LMNANOTUMERCC1ERCC4KAT6A | |
| Hydrochloric Acid SCHEMBL6006151 | 0.77 | NOTUM (0.55) | LMNANOTUMERCC1ERCC4KAT6A | |
| SCHEMBL28677811 | 0.76 | GRIN1 (0.53) | RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL28677810 | 0.76 | NOTUM (0.49) | RXRAGRIN1GRIN2BNOTUMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107903251-A | Pyrazole formylamine derivate as the TAAR conditioning agents for treating several conditions such as depression, diabetes and Parkinson's | 霍夫曼-拉罗奇有限公司 | 2018-04-13 | — | — | CN | disclosed |
| CN-103596937-B | Substituted benzamide derivatives | 霍夫曼-拉罗奇有限公司 | 2016-06-29 | — | — | CN | disclosed |