Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TGM2 | P21980 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223210 | 0.97 | HTT (0.67) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL7364819 | 0.91 | LMNA (0.65) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL1299850 | 0.89 | HTT (0.72) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL7877730 | 0.89 | HTT (0.72) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL18254066 | 0.89 | HTT (0.81) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL19880178 | 0.88 | HTT (0.56) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL8290406 | 0.88 | HTT (0.70) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL2402780 | 0.88 | HTT (0.74) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL15346534 | 0.88 | HTT (0.79) | HTTTGM2LMNASMN1; SMN2KEAP1 | |
| SCHEMBL9874334 | 0.88 | HTT (0.79) | HTTTGM2LMNASMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180290980-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2018-10-11 | — | — | US | disclosed |
| US-20170000784-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2017-01-05 | — | — | US | disclosed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | disclosed |
| US-9221760-B2 | Autophagy inhibitors | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| WO-2015085229-A1 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-06-11 | — | — | WO | disclosed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2012154879-A2 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2012-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | BECN1, ATG7, SQSTM1 | HTT 918/4885TGM2 1556/4885LMNA 2419/4885 |
| US-20170000784-A1 | Autophagy Inhibitors | BRAF, HRAS, NRAS | HTT 2443/4885TGM2 3236/4885LMNA 1164/4885 |
| US-20140148451-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | HTT 918/4885TGM2 1556/4885LMNA 2419/4885 |
| US-20160137607-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | HTT 918/4885TGM2 1556/4885LMNA 2419/4885 |
| US-20180290980-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | HTT 918/4885TGM2 1556/4885LMNA 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.