Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252621 | 0.77 | DPP9 (0.40) | NAMPTTAS1R3TAS1R1TAS1R2HSP90B1 | |
| SCHEMBL2533362 | 0.76 | NOTUM (0.64) | NOTUMNAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL29758685 | 0.76 | NOTUM (0.64) | NOTUMNAMPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL304994 | 0.73 | HDAC3 (0.43) | NOTUMNAMPTHSD17B3TAS1R3TAS1R1 | |
| SCHEMBL29950507 | 0.73 | HDAC3 (0.43) | NOTUMNAMPTHSD17B3TAS1R3TAS1R1 | |
| SCHEMBL15323808 | 0.72 | HSD17B3 (0.40) | NOTUMNAMPTHSD17B3TAS1R3TAS1R1 | |
| SCHEMBL13236581 | 0.72 | MAOA (0.45) | HSD17B3MEN1MAPTKMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7007436 | 0.71 | HDAC3 (0.43) | NOTUMNAMPTHSD17B3TAS1R3TAS1R1 | |
| Indene SCHEMBL30959780 | 0.71 | CA2 (0.47) | NOTUMHSD17B3MAPT | |
| Indene SCHEMBL6700608 | 0.71 | CA2 (0.47) | NOTUMHSD17B3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707358-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | Abbvie Deutschland GmbH & Co. KG (DE) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012152915-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBOTT GMBH & CO. KG (DE) | 2012-11-15 | — | — | WO | disclosed |