SCHEMBL13739403

SCHEMBL13739403

Cc1cc(C(=O)C(=O)O)c(C)n1-c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 1.00
NOTUM Q6P988 8/20 0.77
HTT P42858 1/20 0.74
GFER P55789 1/20 0.74
SMN1; SMN2 Q16637 2/20 0.72
MAPK1 P28482 2/20 0.63
MAPT P10636 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
USP14 P54578 1/20 0.56
USP7 Q93009 1/20 0.56
POLB P06746 2/20 0.56
LMNA P02545 2/20 0.53
NR1H4 Q96RI1 1/20 0.52
HPGD P15428 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1980763 0.87 NOTUM (1.00) ALDH1A1NOTUMSMN1; SMN2MAPK1MAPT
SCHEMBL28017620 0.83 NOTUM (0.74) ALDH1A1NOTUMHTTGFERSMN1; SMN2
SCHEMBL13739808 0.81 MAPK1 (0.76) ALDH1A1NOTUMHTTGFERSMN1; SMN2
SCHEMBL13832874 0.80 ALDH1A1 (0.67) ALDH1A1NOTUMHTTGFERSMN1; SMN2
SCHEMBL14226141 0.80 NOTUM (0.70) ALDH1A1NOTUMHTTSMN1; SMN2MAPK1
SCHEMBL13740783 0.80 ALDH1A1 (0.72) ALDH1A1NOTUMHTTSMN1; SMN2MAPK1
SCHEMBL13832753 0.79 ALDH1A1 (0.65) ALDH1A1NOTUMHTTGFERSMN1; SMN2
SCHEMBL13832765 0.79 NOTUM (0.68) ALDH1A1NOTUMHTTSMN1; SMN2MAPK1
SCHEMBL13739724 0.79 NOTUM (0.68) ALDH1A1NOTUMHTTGFERSMN1; SMN2
SCHEMBL13832658 0.78 NOTUM (0.67) ALDH1A1NOTUMSMN1; SMN2MAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12180189-B2 Proteostasis regulators Kineta, Inc. (US) 2024-12-31 US disclosed
US-20200299270-A1 PROTEOSTASIS REGULATORS Kineta, Inc. 2020-09-24 US disclosed
US-20200299270-A1 PROTEOSTASIS REGULATORS Kineta, Inc. 2020-09-24 US disclosed
EP-3552664-A1 PROTEOSTASIS REGULATORS Proteostasis Therapeutics, Inc. (US) 2019-10-16 EP disclosed
EP-3552664-A1 PROTEOSTASIS REGULATORS Proteostasis Therapeutics, Inc. (US) 2019-10-16 EP disclosed
EP-2707101-B1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS INC (US) 2019-02-13 EP disclosed
EP-2707101-B1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS INC (US) 2019-02-13 EP disclosed
US-20170247355-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2017-08-31 US disclosed
US-20170247355-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2017-08-31 US disclosed
US-20170247355-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2017-08-31 US disclosed
US-9556166-B2 Proteostasis regulators PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-01-31 US disclosed
US-9556166-B2 Proteostasis regulators PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-01-31 US disclosed
US-9556166-B2 Proteostasis regulators PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-01-31 US disclosed
EP-2707101-A1 PROTEOSTASIS REGULATORS Proteostasis Therapeutics, Inc. (US) 2014-03-19 EP disclosed
CN-103635230-A Proteostasis regulators PROTEOSTASIS THERAPEUTICS INC 2014-03-12 CN disclosed
US-20120316193-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2012-12-13 US disclosed
US-20120316193-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2012-12-13 US disclosed
US-20120316193-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. 2012-12-13 US disclosed
WO-2012154967-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. (US) 2012-11-15 WO disclosed
WO-2012154967-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. (US) 2012-11-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200299270-A1 PROTEOSTASIS REGULATORS PSMG3, VCP, HSPA5 ALDH1A1 3419/4885NOTUM 3292/4885HTT 234/4885
US-20170247355-A1 PROTEOSTASIS REGULATORS PSMG3, VCP, HSPA5 ALDH1A1 3419/4885NOTUM 3292/4885HTT 234/4885
US-12180189-B2 Proteostasis regulators PSMG3, VCP, HSPA5 ALDH1A1 3419/4885NOTUM 3292/4885HTT 234/4885
US-20120316193-A1 PROTEOSTASIS REGULATORS PSMG3, VCP, HSPA5 ALDH1A1 3419/4885NOTUM 3292/4885HTT 234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.