Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738754 | 0.76 | PRKDC (0.35) | MAPTALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL13740852 | 0.73 | PRKDC (0.36) | MAPTALDH1A1POLBKDM4ERAB9A | |
| SCHEMBL7070583 | 0.73 | ALOX5 (0.41) | ALDH1A1 | |
| SCHEMBL13738143 | 0.73 | MCHR1 (0.35) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL12777778 | 0.71 | MAPT (0.45) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL5770536 | 0.68 | MAPT (0.58) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL2169920 | 0.68 | MAPT (0.43) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL28122768 | 0.65 | CCR1 (0.45) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL3978958 | 0.64 | TP53 (0.48) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL13739552 | 0.64 | GSK3B (0.55) | MAPTALDH1A1POLBIKBKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707101-A1 | PROTEOSTASIS REGULATORS | Proteostasis Therapeutics, Inc. (US) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012154967-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |