SCHEMBL13738754

SCHEMBL13738754

Cc1sc(-c2ccc(Cl)cc2)cc1C(C=O)N1CCCCC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 1/20 0.35
NPSR1 Q6W5P4 3/20 0.35
MEN1 O00255 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
HRH3 Q9Y5N1 4/20 0.34
CHRNA1 P02708 1/20 0.34
CHRNG P07510 1/20 0.34
CHRNB1 P11230 1/20 0.34
CHRNB2 P17787 1/20 0.34
SLC6A2 P23975 1/20 0.34
CHRNB4 P30926 1/20 0.34
SLC6A4 P31645 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CHRND Q07001 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13740852 0.87 PRKDC (0.36) PRKDCMCHR1ALDH1A1POLBMAPT
SCHEMBL13738143 0.86 MCHR1 (0.35) PRKDCMCHR1ALDH1A1POLBMAPT
SCHEMBL13739554 0.76 MAPT (0.39) PRKDCNPSR1MEN1KMT2AALDH1A1
SCHEMBL20772782 0.76 HSD17B2 (0.40) PRKDCNPSR1CHRNA1CHRNGCHRNB1
SCHEMBL27940194 0.73 NTSR1 (0.44) CYP3A4CYP2D6CYP2C19HRH3MCHR1
SCHEMBL20772370 0.68 HSD17B2 (0.43) PRKDCMEN1CYP3A4CYP2D6CYP2C19
SCHEMBL13738624 0.68 THRB (0.43) NPSR1ALDH1A1POLBMAPTLMNA
SCHEMBL20772829 0.66 HSD17B2 (0.39) PRKDCNPSR1CYP2C9CYP2C19ALDH1A1
SCHEMBL13832852 0.66 USP14 (0.56) NPSR1MEN1KMT2AALDH1A1MAPT
SCHEMBL10279359 0.65 TRPV1 (0.35) NPSR1MEN1KMT2AMCHR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2707101-A1 PROTEOSTASIS REGULATORS Proteostasis Therapeutics, Inc. (US) 2014-03-19 EP disclosed
WO-2012154967-A1 PROTEOSTASIS REGULATORS PROTEOSTASIS THERAPEUTICS, INC. (US) 2012-11-15 WO disclosed