Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.65 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30908198 | 0.89 | HDAC1 (0.66) | HDAC2HDAC3HDAC1HTTKCNK3 | |
| SCHEMBL10644415 | 0.85 | HDAC2 (0.66) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL6774875 | 0.82 | KDM4C (0.42) | KDM4DKDM4CHDAC2HDAC3HDAC1 | |
| SCHEMBL14439746 | 0.82 | KDM4D (0.68) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL2224452 | 0.82 | RAB9A (0.67) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL28561950 | 0.80 | KDM4D (0.69) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL5922458 | 0.80 | KDM4D (0.60) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL12320459 | 0.79 | KDM4D (0.68) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL30599581 | 0.79 | KDM4D (0.68) | KDM4DKDM4CJAK2TYK2NAMPT | |
| SCHEMBL27598170 | 0.79 | KDM4D (0.68) | KDM4DKDM4CJAK2TYK2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | KDM4D 1411/4885KDM4C 1163/4885JAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.