Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13740631 | 0.94 | CYP1A2 (0.37) | CYP1A2CYP2D6CACNA2D1NPY5RKDM4E | |
| SCHEMBL13739508 | 0.91 | CACNA2D1 (0.41) | CACNA2D1NPY5RPOLBKMT2A | |
| SCHEMBL13739819 | 0.87 | PTGDR2 (0.34) | CYP1A2CYP2D6CRHR1IDO1KDM4E | |
| SCHEMBL13737764 | 0.85 | USP2 (0.48) | CYP1A2CYP2D6KDM4EMEN1ALDH1A1 | |
| SCHEMBL15732882 | 0.82 | ANPEP (0.33) | CYP1A2CYP2D6CRHR1IDO1KDM4E | |
| SCHEMBL13739384 | 0.79 | USP2 (0.45) | CYP1A2CYP2D6KDM4EMEN1ALDH1A1 | |
| SCHEMBL15732851 | 0.79 | CHRM2 (0.38) | CYP1A2CYP2D6CRHR1KDM4EMEN1 | |
| SCHEMBL15732999 | 0.77 | ACHE (0.47) | — | |
| SCHEMBL15732853 | 0.77 | ACHE (0.44) | — | |
| SCHEMBL13832346 | 0.77 | KMT2A (0.51) | CYP1A2KDM1ACACNA2D1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | claimed |
| US-20180290980-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2018-10-11 | — | — | US | claimed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | claimed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | claimed |
| WO-2012154879-A2 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2012-11-15 | — | — | WO | claimed |
| US-10544100-B2 | Autophagy inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180290980-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2018-10-11 | — | — | US | disclosed |
| US-20170000784-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2017-01-05 | — | — | US | disclosed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | disclosed |
| US-9221760-B2 | Autophagy inhibitors | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | BECN1, ATG7, SQSTM1 | CYP1A2 2734/4885CYP2D6 3224/4885KDM1A 2833/4885 |
| US-20170000784-A1 | Autophagy Inhibitors | BRAF, HRAS, NRAS | CYP1A2 948/4885CYP2D6 2818/4885KDM1A 1747/4885 |
| US-20140148451-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | CYP1A2 2734/4885CYP2D6 3224/4885KDM1A 2833/4885 |
| US-20160137607-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | CYP1A2 2734/4885CYP2D6 3224/4885KDM1A 2833/4885 |
| US-20180290980-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | CYP1A2 2734/4885CYP2D6 3224/4885KDM1A 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.