Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11954391 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL9914081 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL16491129 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL12311766 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL11946930 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL24988552 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL14025402 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL14556001 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL12311769 | 0.95 | THRB (0.38) | THRBLMNATYR | |
| SCHEMBL11083921 | 0.95 | THRB (0.38) | THRBLMNATYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230134986-A1 | GLUCOSE TRIPTOLIDE CONJUGATES AND USES THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20170145046-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | CLINIGEN GROUP PLC (GB) | 2017-05-25 | — | — | US | disclosed |
| US-20140031539-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | Biocodex, Inc (US) | 2014-01-30 | — | — | US | disclosed |
| US-20090209535-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | TOPOTARGET A/S (DK) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031539-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | TOP2A, TOP2B, TOP1 | THRB 3832/4885LMNA 1695/4885TYR 3396/4885 |
| US-20090209535-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | TOP2A, TOP1, TOP2B | THRB 2665/4885LMNA 586/4885TYR 4352/4885 |
| US-20230134986-A1 | GLUCOSE TRIPTOLIDE CONJUGATES AND USES THEREOF | SLC2A1, SLC2A9, GID4 | THRB 1349/4885LMNA 4637/4885TYR 2531/4885 |
| US-20170145046-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | TOP2A, TOP1, TOP2B | THRB 2469/4885LMNA 582/4885TYR 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.