Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534172 | 0.81 | POLB (0.60) | POLBLMNATP53THRBTSHR | |
| SCHEMBL14361065 | 0.79 | POLB (0.55) | POLBLMNATP53THRBTSHR | |
| SCHEMBL8324919 | 0.79 | POLB (0.57) | POLBLMNATP53THRBTSHR | |
| SCHEMBL534085 | 0.79 | POLB (0.73) | POLBLMNATP53THRB | |
| SCHEMBL1466311 | 0.67 | NPSR1 (0.56) | POLBTSHRALDH1A1 | |
| SCHEMBL13744464 | 0.64 | NR1I2 (0.39) | LMNATSHRMAPK1ALDH1A1ESR1 | |
| SCHEMBL13744726 | 0.63 | KEAP1 (0.46) | TSHRALDH1A1 | |
| SCHEMBL10092343 | 0.61 | KEAP1 (0.42) | POLBMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL9632119 | 0.60 | SLC6A1 (0.33) | ALDH1A1APEX1RECQLTDP1L3MBTL1 | |
| SCHEMBL1466367 | 0.59 | LOX (0.41) | POLBLMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579340-B2 | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists | PFIZER INC (US) | 2009-08-25 | — | — | US | disclosed |