Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.77 |
| ▸ | HTR1A | P08908 | 3/20 | 0.74 |
| ▸ | BCHE | P06276 | 2/20 | 0.74 |
| ▸ | ACHE | P22303 | 2/20 | 0.74 |
| ▸ | HTR1B | P28222 | 2/20 | 0.74 |
| ▸ | HTR2A | P28223 | 2/20 | 0.74 |
| ▸ | HTR2C | P28335 | 2/20 | 0.74 |
| ▸ | HTR2B | P41595 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394464 | 0.89 | MTNR1A (0.90) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL11468610 | 0.86 | MTNR1A (0.97) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL4977581 | 0.84 | ADRA2A (0.61) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL19411584 | 0.82 | MTNR1A (0.77) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL5463853 | 0.81 | MEN1 (0.63) | MTNR1AKMT2AMEN1PKMCYP1A2 | |
| SCHEMBL5130210 | 0.79 | HDAC1 (0.57) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL9358598 | 0.79 | MTNR1A (0.72) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL10113302 | 0.79 | MTNR1A (0.68) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL13203825 | 0.79 | MTNR1A (0.68) | MTNR1AHTR1ABCHEACHEHTR1B | |
| SCHEMBL10114080 | 0.78 | MTNR1A (0.67) | MTNR1AHTR1ABCHEACHEHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098282-A1 | LOW MOLECULAR WEIGHT 2,5-DISUBSTITUTED THIOPHENE DERIVATIVES AND USE THEREOF IN THERAPY | NOVASAID AB (SE) | 2009-08-13 | — | — | WO | disclosed |