Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 8/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746788 | 0.86 | SCARB1 (0.56) | SCARB1HSD17B10 | |
| SCHEMBL13746624 | 0.81 | SCARB1 (0.60) | SCARB1HSD17B10NPC1CNR2RORC | |
| SCHEMBL4030140 | 0.81 | SCARB1 (0.59) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL4027183 | 0.80 | SCARB1 (0.70) | SCARB1HSD17B10RORCPTGDR2ALDH1A1 | |
| SCHEMBL4030106 | 0.79 | SCARB1 (0.61) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL4030252 | 0.79 | SCARB1 (0.70) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL4189175 | 0.76 | SCARB1 (0.69) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL4028758 | 0.76 | SCARB1 (0.72) | SCARB1HSD17B10NPC1CNR2RORC | |
| SCHEMBL4024931 | 0.76 | SCARB1 (0.69) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL13746723 | 0.75 | SCARB1 (0.64) | SCARB1HSD17B10NPC1RORCPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |