Sugi Predict

Sugi Predict / Compounds / SCHEMBL137476

SCHEMBL137476

SCHEMBL137476

O=C(Cl)OCc1ccc(Cl)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.67
▸ L3MBTL1 Q9Y468 3/20 0.50
▸ MMP2 P08253 2/20 0.50
▸ NPSR1 Q6W5P4 2/20 0.50
▸ IDO1 P14902 2/20 0.50
▸ AGXT P21549 2/20 0.50
▸ MMP1 P03956 1/20 0.50
▸ MMP9 P14780 1/20 0.50
▸ MMP12 P39900 1/20 0.50
▸ CYP1A2 P05177 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ MEN1 O00255 3/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ MAPT P10636 2/20 0.49
▸ NR4A2 P43354 1/20 0.49
▸ POLB P06746 1/20 0.47
▸ P2RX4 Q99571 1/20 0.47
▸ MAOA P21397 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8021350 0.91 ALDH1A1 (0.78) ALDH1A1L3MBTL1MMP2NPSR1MMP1
SCHEMBL6646522 0.84 MEN1 (0.54) ALDH1A1L3MBTL1MMP2NPSR1IDO1
SCHEMBL28142 0.84 IDO1 (0.52) ALDH1A1L3MBTL1MMP2NPSR1IDO1
SCHEMBL12992908 0.83 ALDH1A1 (0.67) ALDH1A1L3MBTL1MEN1KMT2APOLB
SCHEMBL8197936 0.83 ALDH1A1 (0.54) ALDH1A1L3MBTL1MMP2NPSR1IDO1
SCHEMBL18279602 0.83 ALDH1A1 (0.50) ALDH1A1L3MBTL1MMP2NPSR1IDO1
SCHEMBL11571335 0.81 ALDH1A1 (0.64) ALDH1A1IDO1CYP3A4MEN1KMT2A
SCHEMBL2301055 0.81 GAA (0.55) ALDH1A1L3MBTL1MMP2NPSR1IDO1
SCHEMBL7138704 0.81 ALDH1A1 (0.64) ALDH1A1L3MBTL1MEN1KMT2AMAPT
SCHEMBL11868697 0.81 ALDH1A1 (0.64) ALDH1A1L3MBTL1NPSR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922329-B Process and intermediates for the preparation of water-soluble taxane derivatives 江苏恩华络康药物研发有限公司 2020-11-24 — — CN claimed
CN-110627832-A Preparation method for synthesizing tenofovir alafenamide by oxidation method 江西农业大学 2019-12-31 — — CN claimed
CN-107922329-A It is used to prepare the method and intermediate of water-soluble taxane analog derivative 江苏恩华络康药物研发有限公司 2018-04-17 — — CN claimed
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2025-09-02 — — US disclosed
US-20250236627-A1 CERTAIN OCTAHYDROFURO[3,4- B]PYRAZINES AS GLP-1 RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2025-07-24 — — US disclosed
US-20240417393-A1 CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AS GLP-1 RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2024-12-19 — — US disclosed
US-20240299559-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF MONTE ROSA THERAPEUTICS AG (CH) 2024-09-12 — — US disclosed
EP-4412707-A1 CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AS GLP-1 RECEPTOR MODULATORS Astrazeneca AB (SE) 2024-08-14 — — EP disclosed
CN-118103366-A Certain 2, 5-diazabicyclo [4.2.0] octanes as GLP-1 receptor modulators 阿斯利康(瑞典)有限公司 2024-05-28 — — CN disclosed
CN-118047785-A Method for preparing Wu Pati Ni and intermediate thereof 和鼎（南京）医药技术有限公司 2024-05-17 — — CN disclosed
US-11970481-B1 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2024-04-30 — — US disclosed
US-4369325-A ANTIPHLOGISTIC AND DIURETIC ACTIVITY EGYT GYOGYSZERVEGYESZETI GYAR (HU) 1983-01-18 — — US disclosed
US-4358606-A Esters of phenalkyloxycarbonylamino acids ZOECON CORPORATION (US) 1982-11-09 — — US disclosed
US-4323387-A N-Thiolcarbonyl derivatives of N-phosphonomethylglycinonitrile esters, herbicidal compositions and use thereof MONSANTO COMPANY (US) 1982-04-06 — — US disclosed
US-4228168-A ANTI-ANOXIC ACTIVITY TANABE SEIYAKU CO., LTD. (JP) 1980-10-14 — — US disclosed
US-4069340-A ARYLOXY DIMETHYL IMMONIUM CHLORIDES FROM DIMETHYL FORMAMIDE AND CORRESPONDING ARYL CHLOROFORMATES HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1978-01-17 — — US disclosed
US-4000297-A GASTROENTERIC ACTIVITY ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1976-12-28 — — US disclosed
US-3983178-A Immonium salts and derivatives thereof HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-09-28 — — US disclosed
US-3936452-A Process of producing pyrimidyl thiocarbonates NITTO BOSEKI CO., LTD. (JA) 1976-02-03 — — US disclosed
US-3932375-A PROTECTING GROUPS NITTO BOSEKI CO. LTD. (JA) 1976-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 ALDH1A1 3991/4885L3MBTL1 949/4885MMP2 2912/4885
US-11970481-B1 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 ALDH1A1 3991/4885L3MBTL1 949/4885MMP2 2912/4885
US-20240299559-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF CDK2, SKP2, CDK1 ALDH1A1 3818/4885L3MBTL1 1254/4885MMP2 2652/4885
US-20240417393-A1 CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AS GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, GPR119 ALDH1A1 1404/4885L3MBTL1 3307/4885MMP2 4351/4885
US-20250236627-A1 CERTAIN OCTAHYDROFURO[3,4- B]PYRAZINES AS GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, GPR119 ALDH1A1 746/4885L3MBTL1 3155/4885MMP2 3680/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.