Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 4/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.53 |
| ▸ | FNTA | P49354 | 2/20 | 0.52 |
| ▸ | FNTB | P49356 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.51 |
| ▸ | PPARA | Q07869 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374838 | 1.00 | NPY5R (0.58) | NPY5RROCK2HDAC8S1PR1LTA4H | |
| SCHEMBL10176502 | 0.92 | ROCK2 (0.60) | ROCK2HDAC8LTA4HBACE1 | |
| SCHEMBL21880195 | 0.92 | ROCK2 (0.60) | ROCK2HDAC8LTA4HBACE1 | |
| SCHEMBL6663334 | 0.92 | ROCK2 (0.60) | ROCK2HDAC8LTA4HBACE1 | |
| SCHEMBL1375609 | 0.88 | LTA4H (0.56) | NPY5RS1PR1LTA4HFNTAFNTB | |
| SCHEMBL1375610 | 0.88 | LTA4H (0.56) | NPY5RS1PR1LTA4HFNTAFNTB | |
| SCHEMBL1372246 | 0.85 | S1PR1 (0.58) | NPY5RS1PR1LTA4HFNTAFNTB | |
| SCHEMBL1372249 | 0.85 | S1PR1 (0.58) | NPY5RS1PR1LTA4HFNTAFNTB | |
| SCHEMBL6665555 | 0.83 | KMT2A (0.65) | ROCK2HDAC8LTA4HBACE1 | |
| SCHEMBL30452307 | 0.83 | KMT2A (0.65) | ROCK2HDAC8LTA4HBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791102-B2 | Acetanilide sphingosine-1-phosphate receptor antagonists | EXELIXIS, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110288076-A1 | Sphingosine-1-Phosphate Receptor Antagonists | EXELIXIS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| CN-102256944-A | Sphingosine-1-phosphate receptor antagonists | EXELIXIS INC | 2011-11-23 | — | — | CN | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288076-A1 | Sphingosine-1-Phosphate Receptor Antagonists | S1PR1, S1PR2, S1PR3 | NPY5R 966/4885ROCK2 759/4885HDAC8 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.