Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.47 |
| ▸ | GIPR | P48546 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251290 | 0.90 | GCGR (0.45) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253028 | 0.88 | GCGR (0.62) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667496 | 0.87 | GCGR (0.42) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13748634 | 0.87 | GCGR (0.46) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253932 | 0.85 | GCGR (0.48) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667403 | 0.85 | GCGR (0.64) | GCGRGIPR | |
| SCHEMBL13749330 | 0.81 | GCGR (0.44) | GCGRGIPRCYP2C9 | |
| SCHEMBL2254697 | 0.81 | MAPT (0.47) | GCGRGIPRHDAC1HDAC6 | |
| SCHEMBL2250997 | 0.79 | GCGR (0.45) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2250281 | 0.77 | GCGR (0.43) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572922-B2 | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-08-11 | — | — | US | disclosed |