Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.80 |
| ▸ | HPGD | P15428 | 7/20 | 0.80 |
| ▸ | CASP1 | P29466 | 6/20 | 0.80 |
| ▸ | TSHR | P16473 | 4/20 | 0.80 |
| ▸ | CASP7 | P55210 | 4/20 | 0.80 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | GLA | P06280 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KLK7 | P49862 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731467 | 0.91 | MAPT (0.85) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL13731195 | 0.90 | MAPT (0.83) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL13723869 | 0.90 | ALDH1A1 (0.82) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL13731982 | 0.89 | MAPT (1.00) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL13749385 | 0.89 | KDM4E (1.00) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL4088135 | 0.87 | HSD17B10 (0.78) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL31351809 | 0.83 | KDM4E (0.64) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL13730390 | 0.83 | MAPT (0.72) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL31351821 | 0.82 | KDM4E (0.67) | MAPTKDM4EHSD17B10HPGDCASP1 | |
| SCHEMBL4209297 | 0.81 | ALDH1A1 (0.75) | MAPTKDM4EHSD17B10HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |