Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.81 |
| ▸ | HPGD | P15428 | 11/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.81 |
| ▸ | CASP1 | P29466 | 4/20 | 0.81 |
| ▸ | TSHR | P16473 | 3/20 | 0.81 |
| ▸ | CASP7 | P55210 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | KLK7 | P49862 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731467 | 0.92 | MAPT (0.85) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL13731195 | 0.91 | MAPT (0.83) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL13749385 | 0.90 | KDM4E (1.00) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL14014115 | 0.89 | MAPT (0.80) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL13730390 | 0.84 | MAPT (0.72) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL31351804 | 0.80 | KDM4E (0.77) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL31351806 | 0.80 | KDM4E (0.77) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL4203906 | 0.79 | HPGD (0.83) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL14013782 | 0.78 | ALDH1A1 (0.79) | MAPTKDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL4204293 | 0.78 | KDM4E (1.00) | MAPTKDM4EHPGDHSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699577-A1 | TETRAHYDROPYRAZOLO [1,5 -A]PYRIMIDINE AS ANTI -TUBERCULOSIS COMPOUNDS | Glaxo Group Limited (GB) | 2014-02-26 | — | — | EP | disclosed |
| US-20140038989-A1 | TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2014-02-06 | — | — | US | disclosed |
| WO-2012143522-A1 | TETRAHYDROPYRAZOLO [1,5 -A] PYRIMIDINE AS ANTI -TUBERCULOSIS COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038989-A1 | TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS | TBL3, NDUFV3, NME2 | MAPT 3921/4885KDM4E 1762/4885HPGD 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.