Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736870 | 0.80 | RAB9A (0.50) | SMN1; SMN2KMT2ANPSR1MAOBLMNA | |
| SCHEMBL1405221 | 0.79 | ELANE (0.47) | SMN1; SMN2KMT2AMAOBKDM4EGAA | |
| SCHEMBL28397010 | 0.79 | ELANE (0.49) | SMN1; SMN2KMT2AMEN1KDM4EGAA | |
| SCHEMBL26500824 | 0.79 | KDM4E (0.47) | KDM4EATMALDH1A1 | |
| SCHEMBL28894377 | 0.79 | KMT2A (0.48) | KMT2AMEN1KDM4EGAAATM | |
| SCHEMBL660921 | 0.79 | LMNA (0.64) | SMN1; SMN2KMT2ANPSR1MAOBLMNA | |
| SCHEMBL1665241 | 0.78 | KMT2A (0.53) | SMN1; SMN2KMT2ALMNAMEN1KDM4E | |
| SCHEMBL32665655 | 0.78 | HSD17B10 (0.59) | SMN1; SMN2KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL28742677 | 0.77 | CA2 (0.48) | SMN1; SMN2KMT2ALMNAMEN1KDM4E | |
| SCHEMBL5778741 | 0.77 | MAPT (0.53) | SMN1; SMN2KMT2ANPSR1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |