Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13755325 | 0.88 | — | — | |
| SCHEMBL28866941 | 0.88 | — | — | |
| SCHEMBL21672495 | 0.77 | ADRA1A (0.33) | ADRA1ADRD4 | |
| SCHEMBL15729571 | 0.73 | ADRA1A (0.30) | ADRA1A | |
| SCHEMBL17091036 | 0.73 | POLB (0.31) | ADRA1A | |
| SCHEMBL25159147 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL30194868 | 0.69 | — | — | |
| SCHEMBL11107898 | 0.68 | MGLL (0.31) | HRH3KMT2A | |
| SCHEMBL26780072 | 0.68 | ADRA1A (0.35) | ADRA1A | |
| SCHEMBL19200196 | 0.68 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579344-B2 | Pyrimidine derivatives possessing cell-cycle inhibitors activity | ASTRAZENECA AB (SE) | 2009-08-25 | — | — | US | disclosed |