Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Caramiphen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.84 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.73 |
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Caramiphen SCHEMBL158932 | 1.00 | PRCP (0.84) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Carbetapentane SCHEMBL7614465 | 0.95 | CHRM2 (0.84) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Caramiphen SCHEMBL181285 | 0.92 | PRCP (1.00) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Caramiphen SCHEMBL10898559 | 0.91 | PRCP (0.97) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Caramiphen SCHEMBL1374820 | 0.91 | ALDH1A1 (1.00) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Hydrochloric Acid SCHEMBL7383119 | 0.89 | ALDH1A1 (0.97) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| SCHEMBL8107029 | 0.89 | PRCP (0.95) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Hydrochloric Acid SCHEMBL8107092 | 0.88 | ALDH1A1 (0.95) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Hydrochloric Acid SCHEMBL7384475 | 0.85 | ALDH1A1 (0.90) | PRCPSIGMAR1ALDH1A1POLBCHRM2 | |
| Caramiphen SCHEMBL8735818 | 0.85 | ALDH1A1 (0.88) | PRCPSIGMAR1ALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107847493-A | ANTITUSSIVE COMPOSITIONS AND METHODS | 阿提努公司 | 2018-03-27 | — | — | CN | claimed |
| EP-1651184-B1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS | MCNEIL PPC INC (US) | 2013-05-22 | — | — | EP | claimed |
| CN-101810547-A | Fast dissolving orally consumable films | WARNER LAMBERT CO | 2010-08-25 | — | — | CN | claimed |
| EP-1651184-A1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS | Warner-Lambert Company LLC (US) | 2006-05-03 | — | — | EP | claimed |
| CN-1750809-A | Fast dissolving orally consumable films containing pharmaceutically active agents | WARNER LAMBERT CO (US) | 2006-03-22 | — | — | CN | claimed |
| WO-2004096174-A1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-11-11 | — | — | WO | claimed |
| US-20030206942-A1 | Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent | MCNEIL-PPC, INC | 2003-11-06 | — | — | US | claimed |
| CN-1321080-A | Fast dissolving orally consumable films | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| CN-118593436-A | High performance excipient comprising co-processed microcrystalline cellulose and surface-reacted calcium carbonate | OMYA国际股份公司 | 2024-09-06 | — | — | CN | disclosed |
| US-20200197310-A1 | Technology for Preparation of Macromolecular Microspheres | NEXBIO, INC. | 2020-06-25 | — | — | US | disclosed |
| US-10583086-B2 | Technology for preparation of macromolecular microspheres | ANSUN BIOPHARMA, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-10231938-B2 | Transdermal drug delivery device including an occlusive backing | NOVEN PHARMACEUTICALS, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| CN-109475504-A | Dosage form | OMYA国际股份公司 | 2019-03-15 | — | — | CN | disclosed |
| WO-1996040084-A1 | COMPOSITIONS AND METHODS FOR USE OF PRESSURE SENSITIVE ADHESIVE TRANSDERMAL DEVICES CONTAINING A BIOADHESIVE HUMECTANT | NOVEN PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040086-A2 | COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS | NOVEN PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0743352-A1 | Lubricant composition suitable for application on metal workpieces during hot-forming | TIMCAL AG (CH) | 1996-11-20 | — | — | EP | disclosed |
| CN-1130867-A | Matrix-entrapped beadlet preparation | SMITHKLINE BEECHAM CORP (US) | 1996-09-11 | — | — | CN | disclosed |
| US-5446070-A | Flexible, finite, bioadhesive, therapeutical agent in solid form | NOVER PHARMACEUTICALS, INC. (US) | 1995-08-29 | — | — | US | disclosed |