SCHEMBL1375575

SCHEMBL1375575

c1ccc(-c2c3ccccc3c(-c3cc4ccc5ccccc5c4c4ccccc34)c3ccccc23)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.48
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
ESR1 P03372 3/20 0.42
ESR2 Q92731 3/20 0.42
NQO2 P16083 2/20 0.41
CYP1A2 P05177 3/20 0.41
FYN P06241 2/20 0.41
AHR P35869 2/20 0.41
ABCG2 Q9UNQ0 2/20 0.41
CYP1A1 P04798 1/20 0.41
MAPK3 P27361 1/20 0.41
PAX8 Q06710 1/20 0.41
ALDH1A1 P00352 6/20 0.40
HPGD P15428 4/20 0.40
MAPT P10636 2/20 0.40
ALOX5 P09917 1/20 0.40
HSD17B10 Q99714 4/20 0.39
TSHR P16473 2/20 0.39
HIF1A Q16665 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1375577 0.86 GSTP1 (0.42) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL13010619 0.86 KDM4E (0.39) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL12144401 0.85 KDM4E (0.43) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL20127329 0.83 ABCG2 (0.50) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL12014501 0.83 KDM4E (0.41) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL25784835 0.82 MEN1 (0.43) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL22004936 0.81 ALDH1A1 (0.43) KDM4EMEN1KMT2ANQO2CYP1A2
SCHEMBL20127332 0.81 ABCG2 (0.48) KDM4EMEN1KMT2ACYP1A2FYN
SCHEMBL19181278 0.81 CYP11B1 (0.50) KDM4EMEN1KMT2AESR1ESR2
SCHEMBL27047119 0.80 HPRT1 (0.52) KDM4EMEN1KMT2AESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220393110-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT, COMPOSITION, POWDER, ELECTRONIC EQUIPMENT, AND NOVEL COMPOUND IDEMITSU KOSAN CO.,LTD. (CN) 2022-12-08 US disclosed
US-9006503-B2 Organic electroluminescence devices containing substituted benzo[C]phenanthrenes MERCK PATENT GMBH (DE) 2015-04-14 US disclosed
CN-102282234-B Material for organic electroluminescent device MERCK PATENT GMBH 2014-07-30 CN disclosed
US-8710284-B2 Materials for organic electroluminescent devices containing substituted 10-benzo[c]phenanthrenes MERCK PATENT GMBH (DE) 2014-04-29 US disclosed
US-20140114076-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2014-04-24 US disclosed
CN-102282234-A Material for organic electroluminescent device 2011-12-14 CN disclosed
US-20110288292-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2011-11-24 US disclosed
WO-2010083869-A2 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2010-07-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110288292-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES DDT, DDC, BMI1 KDM4E 1250/4885MEN1 1428/4885KMT2A 617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.