Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377889 | 0.73 | KCNA5 (0.36) | KCNA5CYP19A1TSHRBACE1CYP1A2 | |
| SCHEMBL1377502 | 0.72 | KCNH3 (0.39) | KCNA5CYP19A1KCNH3CYP1A2CYP3A4 | |
| SCHEMBL1380498 | 0.71 | CYP3A4 (0.49) | L3MBTL1KCNA5CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL31508058 | 0.70 | BACE1 (0.42) | KCNH3BACE1 | |
| SCHEMBL1380210 | 0.70 | KCNA5 (0.40) | KCNA5KCNH3BACE1CYP1A2CYP3A4 | |
| SCHEMBL1382631 | 0.69 | CYP1A2 (0.37) | L3MBTL1KCNA5CYP19A1BACE1CYP1A2 | |
| SCHEMBL4197311 | 0.68 | CYP19A1 (0.44) | L3MBTL1KCNA5KIF11CYP19A1CYP1A2 | |
| SCHEMBL3819751 | 0.68 | CYP1A2 (0.35) | L3MBTL1KCNA5CYP19A1BACE1CYP1A2 | |
| SCHEMBL3814663 | 0.66 | BACE1 (0.33) | KCNA5CYP19A1BACE1CYP1A2CYP3A4 | |
| SCHEMBL1380492 | 0.65 | KIF11 (0.35) | KIF11CYP19A1CTSCBACE1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |