Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557773 | 0.74 | CYP19A1 (0.55) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL28036808 | 0.74 | CYP19A1 (0.55) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL10044245 | 0.72 | CYP19A1 (0.49) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL27888098 | 0.71 | CYP19A1 (0.52) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL22303441 | 0.71 | CYP19A1 (0.52) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL10202596 | 0.70 | CYP19A1 (0.47) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL3021832 | 0.70 | CYP19A1 (0.55) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL28276861 | 0.70 | CYP19A1 (0.55) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL31507922 | 0.70 | KCNA5 (0.47) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL74389 | 0.69 | KIF11 (0.61) | CYP19A1L3MBTL1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |