Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779956 | 1.00 | GRM5 (0.53) | GRM5ALDH1A1MAPK1APPTDP1 | |
| SCHEMBL29825848 | 0.93 | APP (0.57) | GRM5ALDH1A1MAPK1APPTDP1 | |
| SCHEMBL8000068 | 0.93 | APP (0.57) | GRM5ALDH1A1MAPK1APPTDP1 | |
| SCHEMBL29868615 | 0.90 | GRM5 (0.46) | GRM5ALDH1A1MAPK1APPTDP1 | |
| SCHEMBL29288691 | 0.89 | GRM5 (0.46) | GRM5ALDH1A1MAPK1APPTDP1 | |
| SCHEMBL22202978 | 0.87 | GRM5 (0.45) | GRM5ALDH1A1MAPK1TDP1C1S | |
| SCHEMBL4528675 | 0.87 | CA12 (0.50) | GRM5ALDH1A1MAPK1TDP1CA12 | |
| SCHEMBL10035460 | 0.87 | ALDH1A1 (0.64) | GRM5ALDH1A1MAPK1CA12CA1 | |
| SCHEMBL14275435 | 0.87 | GRM5 (0.45) | GRM5ALDH1A1MAPK1APPC1S | |
| SCHEMBL22203008 | 0.85 | GRM5 (0.44) | GRM5ALDH1A1MAPK1TDP1C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924191-A | Polysubstituted olefin derivative and preparation method and application thereof | 杭州师范大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-108484499-B | Method for preparing polysubstituted isoquinoline derivative from hydroxylamine and alkyne | 清华大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-109897039-A | A method of preparing pyrrolo- [3,2,1-ij] quinolinone compounds | 中国科学院化学研究所 | 2019-06-18 | — | — | CN | disclosed |
| CN-109776546-A | A method of preparing indoles and pyrroles's ketone compound | 中国科学院化学研究所 | 2019-05-21 | — | — | CN | disclosed |
| CN-108484499-A | The method that multi-substituted isoquinoline derivative is prepared by azanol and alkynes | 清华大学 | 2018-09-04 | — | — | CN | disclosed |
| US-9493494-B2 | Phosphinine oxide derivative and preparation method thereof | KNU-INDUSTRY COOPERATION FOUNDATION (KR) | 2016-11-15 | — | — | US | disclosed |
| US-20150344506-A1 | NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF | KNU-INDUSTRY COOPERATION FOUNDATION (KR) | 2015-12-03 | — | — | US | disclosed |
| US-8530607-B2 | Aromatic ether and alkynyl containing phthalonitriles | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110288254-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-11-24 | — | — | US | disclosed |
| US-8039576-B2 | Aromatic ether and alkynyl containing phthalonitriles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-10-18 | — | — | US | disclosed |
| US-7615300-B2 | Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology | The Board of Regents University and Community College System of Nevada on Behalf of the University of Nevada (US) | 2009-11-10 | — | — | US | disclosed |
| US-7615300-B2 | Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology | The Board of Regents University and Community College System of Nevada on Behalf of the University of Nevada (US) | 2009-11-10 | — | — | US | disclosed |
| US-20090069484-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-03-12 | — | — | US | disclosed |
| US-20070048579-A1 | Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology | Board of Regents University and Community College System of Nevada | 2007-03-01 | — | — | US | disclosed |
| US-20070048579-A1 | Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology | Board of Regents University and Community College System of Nevada | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344506-A1 | NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF | PHOSPHO1, PPIP5K2, ITPA | GRM5 732/4885ALDH1A1 3382/4885MAPK1 1506/4885 |
| US-20110288254-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | PNN, BECN1, ACIN1 | GRM5 4033/4885ALDH1A1 1956/4885MAPK1 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.