Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428873 | 0.83 | HTT (0.56) | HTTALOX15HPGDMAPK1GRM4 | |
| SCHEMBL14530221 | 0.76 | KMT2A (0.44) | RAB9ANPC1TP53SMN1; SMN2MAPT | |
| SCHEMBL11926403 | 0.76 | GRM4 (0.44) | HTTALOX15HPGDMAPK1GRM4 | |
| SCHEMBL13759248 | 0.76 | MAPK14 (0.49) | SMN1; SMN2HTR2AHTR2CKDR | |
| SCHEMBL14530047 | 0.75 | FLT3 (0.41) | KDR | |
| SCHEMBL11926400 | 0.75 | GRM4 (0.44) | HTTALOX15HPGDMAPK1GRM4 | |
| SCHEMBL13758992 | 0.75 | FLT3 (0.41) | RAB9ALMNAHTR2AKDR | |
| SCHEMBL13759001 | 0.74 | KDR (0.49) | ALDH1A1HTR2AHTR2CKDR | |
| SCHEMBL3111551 | 0.73 | GRM4 (0.45) | HTTALOX15HPGDGRM4LMNA | |
| SCHEMBL11926381 | 0.73 | GRM4 (0.43) | HTTALOX15HPGDMAPK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |