Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14530047 | 0.86 | FLT3 (0.41) | FLT3KDRAURKAFLT1CHRNA3 | |
| SCHEMBL425341 | 0.85 | FLT3 (0.43) | FLT3KDRAURKAFLT1LMNA | |
| SCHEMBL13758989 | 0.75 | HTT (0.52) | KDRLMNARAB9AHTR2A | |
| SCHEMBL430653 | 0.71 | FLT3 (0.44) | FLT3KDRAURKAFLT1CHRNA3 | |
| SCHEMBL13759253 | 0.70 | KDR (0.46) | FLT3KDRAURKAFLT1 | |
| SCHEMBL13759248 | 0.69 | MAPK14 (0.49) | FLT3KDRAURKATSHRHTR2A | |
| SCHEMBL13759001 | 0.69 | KDR (0.49) | FLT3KDRTSHRHTR2A | |
| SCHEMBL13759251 | 0.69 | MAPK14 (0.51) | RAB9ATSHR | |
| SCHEMBL13759252 | 0.68 | POLB (0.51) | TSHRHTR2A | |
| SCHEMBL14530221 | 0.67 | KMT2A (0.44) | FLT3KDRLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |