Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13758992 | 0.86 | FLT3 (0.41) | FLT3KDRAURKAFLT1CHRNA3 | |
| SCHEMBL430653 | 0.85 | FLT3 (0.44) | FLT3KDRAURKAFLT1CHRNA3 | |
| SCHEMBL13758989 | 0.75 | HTT (0.52) | KDR | |
| SCHEMBL425341 | 0.71 | FLT3 (0.43) | FLT3KDRAURKAFLT1CHRNA3 | |
| SCHEMBL13759253 | 0.70 | KDR (0.46) | FLT3KDRAURKAFLT1 | |
| SCHEMBL13759248 | 0.70 | MAPK14 (0.49) | FLT3KDRAURKARET | |
| SCHEMBL13759001 | 0.70 | KDR (0.49) | FLT3KDR | |
| SCHEMBL13759251 | 0.69 | MAPK14 (0.51) | — | |
| SCHEMBL13759252 | 0.69 | POLB (0.51) | — | |
| SCHEMBL3107363 | 0.67 | KMT2A (0.41) | KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |