Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3883933 | 0.89 | MET (0.45) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL3879999 | 0.75 | RAB9A (0.51) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL3883729 | 0.73 | AXL (0.51) | CYP2C9 | |
| SCHEMBL3880151 | 0.69 | MAP3K5 (0.40) | MAPTPTK2 | |
| SCHEMBL8141144 | 0.68 | POLB (1.00) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL5313559 | 0.67 | TP53 (0.45) | MAPTALDH1A1LMNACYP2C9 | |
| SCHEMBL18346432 | 0.63 | POLB (0.84) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL13183604 | 0.63 | HTR2A (0.45) | MAPTCYP1A2TDP1 | |
| SCHEMBL8373652 | 0.63 | POLB (0.77) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL27537299 | 0.62 | ADRB1 (0.51) | SMN1; SMN2RAB9ANPC1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566784-B2 | Bicyclic heterocycles as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-28 | — | — | US | disclosed |