SCHEMBL1376115

SCHEMBL1376115

Fc1ccc(-c2[nH]c(C3CCN(c4ccccc4)CC3)cc2-c2ccncc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.72
GCGR P47871 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1376871 0.84 MAPK14 (0.69) MAPK14
SCHEMBL3290870 0.84 MAPK14 (1.00) MAPK14GCGR
SCHEMBL2646818 0.84 MAPK14 (1.00) MAPK14GCGR
SCHEMBL5726974 0.81 MAPK14 (0.78) MAPK14
SCHEMBL7172846 0.81 MAPK14 (0.70) MAPK14GCGR
SCHEMBL5725550 0.80 MAPK14 (0.79) MAPK14GCGR
SCHEMBL5725265 0.80 MAPK14 (0.74) MAPK14GCGR
SCHEMBL5726133 0.78 MAPK14 (0.60) MAPK14
SCHEMBL2662864 0.78 MAPK14 (0.60) MAPK14
SCHEMBL7621334 0.78 MAPK14 (0.75) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4722360-B2 2011-07-13 JP claimed
JP-2003527336-A 2003-09-16 JP claimed
EP-1278520-A4 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS MERCK & CO INC (US) 2003-05-02 EP claimed
EP-1278520-A1 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS Merck & Co., Inc. (US) 2003-01-29 EP claimed
US-6291480-B1 CONTROL OF COCCIDIOSIS IN POULTRY. MERCK & CO., INC. 2001-09-18 US claimed
WO-2001034149-A1 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS MERCK & CO., INC. (US) 2001-05-17 WO claimed
EP-1278520-A4 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS MERCK & CO INC (US) 2003-05-02 EP disclosed
EP-1278520-A1 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS Merck & Co., Inc. (US) 2003-01-29 EP disclosed
US-6291480-B1 CONTROL OF COCCIDIOSIS IN POULTRY. MERCK & CO., INC. 2001-09-18 US disclosed
WO-2001034149-A1 DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS MERCK & CO., INC. (US) 2001-05-17 WO disclosed