Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670561 | 0.89 | SIGMAR1 (0.64) | SIGMAR1KCNH2HRH3TAAR1LMNA | |
| SCHEMBL9671700 | 0.82 | HRH3 (0.74) | SIGMAR1KCNH2HRH3TAAR1LMNA | |
| SCHEMBL9671267 | 0.81 | SIGMAR1 (0.75) | SIGMAR1KCNH2HRH3TAAR1THRA | |
| SCHEMBL14902842 | 0.80 | ALDH1A1 (0.56) | SIGMAR1KCNH2HRH3TAAR1LMNA | |
| SCHEMBL19146986 | 0.80 | SIGMAR1 (0.55) | SIGMAR1KCNH2HRH3TAAR1LMNA | |
| SCHEMBL9670726 | 0.79 | SIGMAR1 (0.79) | SIGMAR1KCNH2HRH3TAAR1THRA | |
| SCHEMBL9670507 | 0.79 | SIGMAR1 (0.79) | SIGMAR1KCNH2HRH3TAAR1THRA | |
| SCHEMBL554550 | 0.78 | AOC3 (0.59) | SIGMAR1KCNH2HRH3TAAR1AOC3 | |
| SCHEMBL10677993 | 0.78 | TAAR1 (0.76) | SIGMAR1KCNH2HRH3TAAR1AOC3 | |
| SCHEMBL2475962 | 0.78 | ESR1 (0.55) | SIGMAR1KCNH2HRH3TAAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4722360-B2 | — | — | 2011-07-13 | — | — | JP | claimed |
| EP-1278520-B1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2006-03-01 | — | — | EP | claimed |
| JP-2003527336-A | — | — | 2003-09-16 | — | — | JP | claimed |
| EP-1278520-A4 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1278520-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | Merck & Co., Inc. (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001034149-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO., INC. (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1278520-B1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2006-03-01 | — | — | EP | disclosed |
| EP-1278520-A4 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1278520-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | Merck & Co., Inc. (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6291480-B1 | CONTROL OF COCCIDIOSIS IN POULTRY. | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |
| WO-2001034149-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO., INC. (US) | 2001-05-17 | — | — | WO | disclosed |