Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274655 | 0.85 | PDE4B (0.52) | PDE4BKDM1A | |
| SCHEMBL18003630 | 0.81 | POLB (0.49) | PTGDR2PDE4BPLA2G1BATG4BPOLB | |
| SCHEMBL3400187 | 0.81 | PDE4B (0.49) | PDE4BKDM1A | |
| SCHEMBL279184 | 0.81 | PDE4B (0.49) | PDE4BKDM1A | |
| SCHEMBL3400190 | 0.81 | PDE4B (0.49) | PDE4BKDM1A | |
| SCHEMBL275132 | 0.76 | PTGDR2 (0.44) | PTGDR2PDE4BPLA2G1BATG4BPOLB | |
| SCHEMBL13815410 | 0.76 | IKBKB (0.48) | IKBKBPDE4BCHUKKMT2AMEN1 | |
| SCHEMBL31370640 | 0.76 | ALDH1A1 (0.55) | IKBKBALKKMT2AMEN1KDM1A | |
| SCHEMBL223707 | 0.75 | GPR119 (0.45) | IKBKBPDE4BCHUKKMT2AMEN1 | |
| SCHEMBL3688993 | 0.75 | MAPT (0.52) | KMT2AMEN1RAB9APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080488-A1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |