Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691360 | 0.83 | BACE1 (0.53) | MAPTALDH1A1RBP4LMNA | |
| SCHEMBL29964224 | 0.83 | BACE1 (0.53) | MAPTALDH1A1RBP4LMNA | |
| SCHEMBL3686814 | 0.82 | HTT (0.44) | MAPTALDH1A1LMNAMAPK1ERN1 | |
| SCHEMBL17403821 | 0.81 | MAPT (0.55) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL6104298 | 0.80 | ALDH1A1 (0.49) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL31485198 | 0.79 | ALDH1A1 (0.64) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16123481 | 0.79 | MAPT (0.54) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16824993 | 0.79 | LMNA (0.67) | MAPTRAB9AALDH1A1HPGDLMNA | |
| SCHEMBL6103643 | 0.79 | ALDH1A3 (0.49) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6103152 | 0.79 | ALDH1A3 (0.49) | MAPTNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |