Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529499 | 0.93 | TLR8 (0.41) | TLR8 | |
| SCHEMBL17012489 | 0.91 | HSD17B10 (0.37) | TLR7TLR8NPC1RAB9A | |
| SCHEMBL13529820 | 0.85 | TLR7 (0.35) | TLR7 | |
| SCHEMBL13530214 | 0.84 | PKM (0.49) | PKMKDM4ENPC1RAB9A | |
| SCHEMBL13530555 | 0.84 | RXRA (0.38) | TLR7TLR8 | |
| SCHEMBL13529578 | 0.83 | TLR7 (0.39) | TLR7 | |
| SCHEMBL20157664 | 0.82 | CYP1A2 (0.42) | TLR7PKMTLR8KDM4ENPC1 | |
| SCHEMBL11604079 | 0.81 | MEN1 (0.36) | TLR7KDM4ENPC1RAB9ACYP3A4 | |
| SCHEMBL13530229 | 0.80 | ROCK2 (0.38) | TLR7 | |
| SCHEMBL13530433 | 0.80 | TLR8 (0.41) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094442-A2 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2009-07-30 | — | — | WO | disclosed |