Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333781 | 0.90 | PDE10A (0.40) | PDE10ALTB4RCYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL4056757 | 0.83 | CYSLTR2 (0.37) | PDE10ACYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL13765233 | 0.80 | PDE10A (0.39) | PDE10ALTB4RCYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL4052528 | 0.79 | LTB4R (0.43) | PDE10ALTB4RCYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL4053392 | 0.76 | CYSLTR1 (0.39) | PDE10ACYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL7801372 | 0.76 | LTB4R (0.43) | PDE10ALTB4RCYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL5335837 | 0.75 | CYSLTR1 (0.39) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL6571774 | 0.73 | ALOX5AP (0.35) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL14159707 | 0.73 | PDE10A (0.39) | PDE10ALTB4RCYSLTR1ALOX5APCYSLTR2 | |
| SCHEMBL4056376 | 0.72 | PDE10A (0.46) | PDE10ACYSLTR1ALOX5APCYSLTR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |