Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765182 | 0.89 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5APPPARG | |
| SCHEMBL13765183 | 0.85 | CYSLTR2 (0.35) | CYSLTR2CYSLTR1LTB4RALOX5APPPARG | |
| SCHEMBL4228194 | 0.85 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1LTB4RALOX5APALOX5 | |
| SCHEMBL5787381 | 0.85 | CYSLTR2 (0.36) | CYSLTR2CYSLTR1LTB4RALOX5APALOX5 | |
| SCHEMBL14159613 | 0.84 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL4063107 | 0.84 | LTB4R (0.37) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL4234235 | 0.84 | CYSLTR2 (0.42) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL4242583 | 0.84 | LTB4R (0.38) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL14159612 | 0.84 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5APPPARG | |
| SCHEMBL4376492 | 0.84 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5APPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |