Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765183 | 0.93 | CYSLTR2 (0.35) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL14159612 | 0.92 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL4229150 | 0.91 | LTB4R (0.36) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R | |
| SCHEMBL13765182 | 0.88 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL4237247 | 0.87 | LTB4R (0.37) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R | |
| SCHEMBL14159613 | 0.86 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R | |
| SCHEMBL4054249 | 0.85 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R | |
| SCHEMBL4063107 | 0.85 | LTB4R (0.37) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R | |
| SCHEMBL13765248 | 0.84 | CYSLTR2 (0.37) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL4230433 | 0.83 | TBXAS1 (0.37) | CYSLTR2CYSLTR1LTB4RALOX5APTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-A1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | Almirall Prodesfarma, S.A. (ES) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043966-A1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL PRODESFARMA S.A. (ES) | 2004-05-27 | — | — | WO | disclosed |