Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765182 | 0.94 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RMAOBPPARG | |
| SCHEMBL4376492 | 0.93 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RMAOBPPARG | |
| SCHEMBL4237247 | 0.91 | LTB4R (0.37) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL4229150 | 0.87 | LTB4R (0.36) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL14159612 | 0.85 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1LTB4RMAOBPPARG | |
| SCHEMBL13765248 | 0.85 | CYSLTR2 (0.37) | CYSLTR2CYSLTR1LTB4RPPARGPPARD | |
| SCHEMBL4228194 | 0.85 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1LTB4RALOX5AP | |
| SCHEMBL4230433 | 0.84 | TBXAS1 (0.37) | CYSLTR2CYSLTR1LTB4RALOX5APKDM4E | |
| SCHEMBL13765202 | 0.84 | TBXAS1 (0.43) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL4052528 | 0.83 | LTB4R (0.43) | CYSLTR2CYSLTR1LTB4RALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |