Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 14/20 | 0.73 |
| ▸ | AR | P10275 | 13/20 | 0.73 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | SHBG | P04278 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16572797 | 1.00 | PGR (0.73) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL13768720 | 1.00 | PGR (0.73) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL12942940 | 1.00 | PGR (0.73) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL13768994 | 0.90 | PGR (0.60) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL12998932 | 0.90 | PGR (0.60) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL12942957 | 0.88 | PGR (0.57) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL13768715 | 0.85 | AR (0.75) | PGRARNR3C2 | |
| SCHEMBL13055678 | 0.85 | PGR (0.56) | PGRARNR3C2LMNASLC6A4 | |
| SCHEMBL16572811 | 0.85 | AR (0.75) | PGRARNR3C2 | |
| SCHEMBL12942947 | 0.85 | AR (0.75) | PGRARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445469-B2 | 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones, as well as pharmaceutical preparations that contain the latter | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-8445469-B2 | 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones, as well as pharmaceutical preparations that contain the latter | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-1831240-B1 | 18-METHYL-19-NOR-17-PREGN-4-EN-21,17-CARBOLACTONES AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | SCHERING AG (DE) | 2009-07-15 | — | — | EP | disclosed |
| US-20090029953-A1 | 18-METHYL-19-NOR-17-PREGN-4-ENE-21,17-CARBOLACTONES, AS WELL AS PHARMACEUTICAL PREPARATIONS THAT CONTAIN THE LATTER | BAYER SCHERING PHARMA AG (DE) | 2009-01-29 | — | — | US | disclosed |
| US-20090029953-A1 | 18-METHYL-19-NOR-17-PREGN-4-ENE-21,17-CARBOLACTONES, AS WELL AS PHARMACEUTICAL PREPARATIONS THAT CONTAIN THE LATTER | BAYER SCHERING PHARMA AG (DE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029953-A1 | 18-METHYL-19-NOR-17-PREGN-4-ENE-21,17-CARBOLACTONES, AS WELL AS PHARMACEUTICAL PREPARATIONS THAT CONTAIN THE LATTER | HSD17B7, HSD17B11, HSD3B1 | PGR 24/4885AR 100/4885NR3C2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.