Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22094603 | 0.84 | BACE1 (0.44) | PTGS1PTGS2SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL14924400 | 0.82 | MAOA (0.50) | NFE2L2MAOAMAOBPTGS1PTGS2 | |
| SCHEMBL13730037 | 0.81 | HSD11B1 (0.56) | MAOAMAOBCYP1A1CYP1B1MMP1 | |
| SCHEMBL13730038 | 0.81 | HSD11B1 (0.56) | MAOAMAOBCYP1A1CYP1B1MMP1 | |
| SCHEMBL29910010 | 0.80 | MAPT (0.53) | MAOAMAOBCYP1A1CYP1B1MMP1 | |
| SCHEMBL13948724 | 0.80 | MAPT (0.53) | MAOAMAOBCYP1A1CYP1B1MMP1 | |
| SCHEMBL31308838 | 0.80 | CYP1A1 (0.48) | NFE2L2PTGS2CYP1A1CYP1B1CA12 | |
| SCHEMBL13489637 | 0.80 | CYP1A1 (0.48) | NFE2L2PTGS2CYP1A1CYP1B1CA12 | |
| SCHEMBL12946587 | 0.80 | NFE2L2 (0.55) | NFE2L2MAOAMAOBPTGS1PTGS2 | |
| SCHEMBL14924042 | 0.79 | TRPV1 (0.42) | MMP1MMP2MMP9SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021779-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2011-01-27 | — | — | US | disclosed |
| WO-2009080335-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021779-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | CYP1B1, CYP1A1, NQO1 | NFE2L2 230/4885MAOA 409/4885MAOB 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.