Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | GCKR | Q14397 | 8/20 | 0.47 |
| ▸ | GCK | P35557 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975333 | 0.84 | POLB (0.63) | LMNASMN1; SMN2USP5TRPV4CDK4 | |
| SCHEMBL13844995 | 0.81 | USP5 (0.56) | LMNASMN1; SMN2USP5KDM4ETRPV4 | |
| SCHEMBL23103946 | 0.79 | POLB (0.59) | SMN1; SMN2GCKRGCKKDM4E | |
| SCHEMBL28511141 | 0.79 | ATM (0.55) | LMNASMN1; SMN2GCKRGCKKDM4E | |
| SCHEMBL29519879 | 0.79 | ATM (0.55) | LMNASMN1; SMN2GCKRGCKKDM4E | |
| SCHEMBL17646020 | 0.78 | POLB (0.67) | SMN1; SMN2GCKKDM4E | |
| SCHEMBL19092139 | 0.77 | KMT2A (0.62) | LMNASMN1; SMN2USP5KDM4ETRPV4 | |
| SCHEMBL19951018 | 0.76 | ALDH1A1 (0.67) | LMNASMN1; SMN2GCKRGCKKDM4E | |
| SCHEMBL20598412 | 0.76 | USP5 (0.56) | LMNASMN1; SMN2USP5KDM4ETRPV4 | |
| SCHEMBL16439685 | 0.76 | MAPT (0.55) | GCKRGCKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085185-A1 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |