Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | USP5 | P45974 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | EBP | Q15125 | 1/20 | 0.55 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.55 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21510346 | 0.88 | KMT2A (0.59) | KMT2AMEN1HTTALDH1A1PKM | |
| SCHEMBL20598412 | 0.86 | USP5 (0.56) | KMT2AMEN1HTTALDH1A1KDM4E | |
| SCHEMBL13844995 | 0.86 | USP5 (0.56) | KMT2AMEN1HTTALDH1A1PKM | |
| SCHEMBL6787299 | 0.84 | KMT2A (0.62) | KMT2AMEN1HTTALDH1A1PKM | |
| SCHEMBL23884723 | 0.83 | USP5 (0.54) | KMT2AMEN1HTTALDH1A1KDM4E | |
| SCHEMBL20884976 | 0.83 | MCOLN3 (0.71) | KMT2AMEN1ALDH1A1POLBUSP5 | |
| SCHEMBL16627296 | 0.82 | HSD11B1 (0.62) | KMT2AMEN1PKMUSP5TRPV4 | |
| SCHEMBL28882522 | 0.81 | ALDH1A1 (0.66) | KMT2AMEN1HTTALDH1A1PKM | |
| SCHEMBL266466 | 0.81 | MEN1 (0.77) | KMT2AMEN1HTTALDH1A1PKM | |
| SCHEMBL20883811 | 0.81 | MCOLN3 (0.56) | KMT2AMEN1HTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210377-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2017114497-A1 | IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY | NOVARTIS AG (CH) | 2017-07-06 | — | — | WO | disclosed |