Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19092139 | 0.86 | KMT2A (0.62) | USP5MEN1KMT2ATRPV4LMNA | |
| SCHEMBL20884976 | 0.85 | MCOLN3 (0.71) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL20598412 | 0.84 | USP5 (0.56) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL3600861 | 0.82 | TSHR (0.56) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL4212319 | 0.82 | MEN1 (0.75) | MEN1KMT2ATDP1LMNAMCOLN3 | |
| SCHEMBL23884723 | 0.82 | USP5 (0.54) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL12315303 | 0.81 | USP5 (0.54) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL13768898 | 0.81 | LMNA (0.48) | USP5TRPV4LMNASMN1; SMN2KDM4E | |
| SCHEMBL16627296 | 0.81 | HSD11B1 (0.62) | USP5MEN1KMT2ATRPV4TDP1 | |
| SCHEMBL16912992 | 0.80 | MEN1 (0.61) | MEN1KMT2ATDP1LMNAMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056693-A1 | NOVEL DERIVATIVES OF N, N'- 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |