Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769799 | 0.88 | SHMT2 (0.49) | MAPTSHMT2ALDH1A1KDM4ETP53 | |
| SCHEMBL13769798 | 0.88 | SHMT2 (0.49) | MAPTSHMT2ALDH1A1KDM4ETP53 | |
| SCHEMBL5538227 | 0.84 | MAPT (0.52) | LGMNMAPTSHMT2ALDH1A1KDM4E | |
| SCHEMBL27543 | 0.80 | LGMN (0.70) | LGMNMAPTSHMT2ALDH1A1KDM4E | |
| SCHEMBL15850037 | 0.77 | MAPT (0.71) | LGMNMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL3142718 | 0.76 | MAPT (0.70) | LGMNMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL17876417 | 0.75 | MAPT (0.65) | LGMNMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL13769801 | 0.75 | S1PR1 (0.46) | MAPTALDH1A1MEN1KMT2AITGB3 | |
| SCHEMBL14167547 | 0.75 | MAPT (0.68) | LGMNMAPTALDH1A1KDM4ETP53 | |
| SCHEMBL1749330 | 0.75 | MAPT (0.68) | LGMNMAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081195-A1 | CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |