Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769799 | 1.00 | SHMT2 (0.49) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13769245 | 0.88 | LGMN (0.56) | SHMT2ALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL5538159 | 0.85 | KDM4E (0.58) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5532095 | 0.85 | KDM4E (0.58) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL21848213 | 0.81 | SHMT2 (0.59) | SHMT2ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL29891157 | 0.78 | ALDH1A1 (0.54) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL22149667 | 0.78 | ALDH1A1 (0.54) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16880167 | 0.78 | ALDH1A1 (0.54) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4684573 | 0.77 | ALDH1A1 (0.58) | SHMT2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL31175186 | 0.77 | ALDH1A1 (0.70) | ALDH1A1KDM4ESMN1; SMN2L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081195-A1 | CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |