Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.52 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | WEE1 | P30291 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31276986 | 0.74 | SMN1; SMN2 (0.57) | KMT2AMEN1LMNASMN1; SMN2KDM4E | |
| SCHEMBL1623659 | 0.73 | GUSB (0.75) | — | |
| SCHEMBL23743247 | 0.72 | POLB (0.57) | CRHR1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL2734535 | 0.72 | PDE10A (0.46) | CRHR1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL31276974 | 0.72 | CYP1A2 (0.73) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL1621708 | 0.72 | METAP1 (0.46) | L3MBTL1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL1463333 | 0.72 | KMT2A (0.65) | KMT2AMEN1LMNASMN1; SMN2KDM4E | |
| SCHEMBL29764078 | 0.72 | KMT2A (0.65) | KMT2AMEN1LMNASMN1; SMN2KDM4E | |
| SCHEMBL27926165 | 0.72 | ALDH1A1 (0.60) | L3MBTL1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL22720142 | 0.70 | KDM4E (0.57) | IDO1TDO2IDO2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |