Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30669482 | 0.79 | POLB (0.48) | KMT2AMEN1GAAMAPTHTT | |
| SCHEMBL182563 | 0.77 | TNKS (0.48) | — | |
| SCHEMBL15426493 | 0.76 | MAP4K1 (0.42) | RPS6KA2 | |
| SCHEMBL183703 | 0.74 | PTGES (0.39) | PDE10ARPS6KA2GRM2 | |
| SCHEMBL13769482 | 0.72 | IDO1 (0.52) | PDE10ACRHR1KMT2AMEN1L3MBTL1 | |
| SCHEMBL12744507 | 0.72 | KMT2A (0.52) | KMT2AMEN1GAAMAPTLMNA | |
| SCHEMBL5986479 | 0.69 | CYP3A4 (0.48) | CYP3A4KMT2AMEN1MAPTLMNA | |
| SCHEMBL1623275 | 0.69 | TNKS (0.50) | MAPTPOLB | |
| SCHEMBL1463978 | 0.68 | KCNH2 (0.60) | CYP3A4KMT2AMEN1HPGDNPSR1 | |
| SCHEMBL1463643 | 0.68 | KCNH2 (0.52) | CYP3A4HPGDNPSR1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |