Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012559 | 0.87 | CCR4 (0.40) | MAPK14P2RX7CCR4EIF2AK3 | |
| SCHEMBL13769756 | 0.82 | VEGFA (0.37) | MAPTCCR4ALDH1A1MEN1KMT2A | |
| SCHEMBL13769532 | 0.79 | PDE4B (0.41) | MAPTALOX5P2RX7PDE4BPDE4D | |
| SCHEMBL4009501 | 0.79 | SCN9A (0.36) | P2RX7CCR4ALDH1A1MEN1KMT2A | |
| SCHEMBL13769525 | 0.77 | MAPT (0.40) | MAPTALOX5P2RX7PDE4BPDE4D | |
| SCHEMBL13769936 | 0.77 | PDE4B (0.42) | MAPTALOX5P2RX7PDE4BPDE4D | |
| SCHEMBL13769676 | 0.77 | MAPT (0.39) | MAPTALOX5P2RX7PDE4BPDE4D | |
| SCHEMBL13769671 | 0.76 | SRC (0.45) | MAPTP2RX7PDE4BPDE4DALDH1A1 | |
| SCHEMBL13769538 | 0.75 | MAPT (0.38) | MAPTALOX5P2RX7PDE4BPDE4D | |
| SCHEMBL13769677 | 0.75 | MAPT (0.38) | MAPTALOX5P2RX7PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |